Reply to: Mannose-binding lectin—the forgotten molecule?

Mannose-binding lectin: ancient molecule, interesting future.

Five hundred sixty-five million years ago, when the world was empty and barren because animal life had not colonized land yet, a common ancestor that we share with sea squirts (Ascidians) inhabited the seas. One of the genes that we still share with sea squirts today is a gene for mannose-binding lectin (MBL), signifying that this gene has existed for 1565 million years [1, 2] and, thus, has be...

P 144: Sunflower Mannose binding Lectin-Associated Serine Protease Inhibitor-1 (SFMI-1) and -2: Significant Inhibitors of Mannose binding Lectin Pathway which Helps in Multiple Sclerosis Treatment

One of the important parts of innate immunity is complement system that occurs in three different ways; the classic, the alternative and the lectin pathway. The four pattern recognition molecules that have been identified till now are Mannose binding lectin (MBL), a component of lectin pathway, and three ficolins (ficolin1,-2 and -3) which compound to the carbohydrates of the cell surface. MBL ...

Mannose-Binding Lectin Binds to Two Major

Mannose-binding lectin and susceptibility to schistosomiasis.

BACKGROUND Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistos...

Mannose-Binding Lectin Binds to a Range